To minimize the risk of "airplane crud," health experts recommend a proactive regimen focused on hydration and barrier protection. Taking a saline nasal spray before and during the flight is one of the most effective steps, as it keeps nasal passages moist and helps the cilia trap viruses in the dry cabin air. Supplementing with Vitamin C, Zinc, and Vitamin D in the days leading up to travel can help prime the immune system, though these are not "magic bullets." For those prone to digestive issues, a probiotic can help maintain gut health during travel-related stress. Additionally, using an alcohol-based hand sanitizer (at least 60% alcohol) frequently is crucial, as tray tables and seat pockets are notorious germ hotspots. Drinking plenty of water—aiming for 8 ounces for every hour in the air—helps prevent dehydration, which can weaken your body's natural defenses. If you are particularly concerned about respiratory illness, wearing a high-quality N95 or FFP2 mask remains the single most effective way to avoid breathing in pathogens from nearby passengers.