In general aviation (GA) under 2026 FAA and ICAO guidelines, you should activate your flight plan immediately after takeoff or once you are clear of the immediate airport environment. For a VFR (Visual Flight Rules) flight plan, filing the plan does nothing until you "activate" it with a Flight Service Station (FSS) or via a digital interface like ForeFlight. This starts the clock for search and rescue (SAR) services; if you do not close the plan within 30 minutes of your estimated arrival time, authorities will begin a search. For IFR (Instrument Flight Rules) pilots, the "activation" happens automatically when you receive your departure clearance and are "identified" on radar by Air Traffic Control. It is a critical safety step to ensure that if you have an emergency, the authorities know your intended route, fuel onboard, and the number of souls on the aircraft.