Throughout 2023, Royal Caribbean's Harmony of the Seas focused its itineraries on the Caribbean, operating primarily from two major U.S. homeports: Miami, Florida, and Galveston, Texas. For the first half of the year, the ship sailed 7-night Eastern and Western Caribbean cruises from Miami, with frequent stops at Royal Caribbean's private island, Perfect Day at CocoCay in the Bahamas. Other popular ports of call included St. Thomas, St. Maarten, Cozumel (Mexico), Costa Maya (Mexico), and Roatán (Honduras). In November 2023, the ship transitioned its homeport to Galveston, Texas, marking the first time an Oasis-class ship was stationed there permanently. From Galveston, it began offering 7-night Western Caribbean itineraries, primarily visiting the Mexican Caribbean and Honduras. These sailings were highly popular for travelers in the central U.S., providing a mega-ship experience without the need to fly to Florida.