Since 1990, the city in which Mickey lives is typically called Mouseton in American comics. In modern continuity, Mouseton is often depicted as being located in the fictional U.S. state of Calisota, analogous to Northern California.

In the "real world," Mickey Mouse resides at the various Disney theme parks, but his most official fictional residence is in Mickey's Toontown at Disneyland Park in California and formerly at Magic Kingdom in Florida. In Toontown, guests can actually walk through his house, see his movie props, and visit his laundry room and kitchen. In the broader lore of Disney comics and cartoons, Mickey is often depicted living in the fictional city of Mouseton, located in the state of Calisota (a portmanteau of California and Minnesota). His "neighborhood" is typically suburban, and he is often shown living in a yellow, red-roofed house. Historically, Walt Disney originally envisioned a "Mickey Mouse Park" directly across from his studio in Burbank, but after the city rejected the plan, Mickey's "home" moved to Anaheim. Today, the most intimate "home" for Mickey remains his cottage in Disneyland, where he has hosted millions of visitors since Toontown opened in 1993.

Mickey Mouse, the iconic cartoon character created by Walt Disney and Ub Iwerks, is most famously associated with Disneyland and Disney World theme parks, where he resides in “Mickey’s Toontown.” In the fictional sense, Mickey Mouse lives in a whimsical, cartoonish version of the world, often depicted as living in the town of Duckburg, California, alongside other Disney characters like Donald Duck and Goofy. His specific residence is typically portrayed as a cozy, cheerful house filled with fun and laughter, befitting his cheerful and adventurous personality.