Popular Royal Caribbean International itneraries include cruises sailing to Alaska, Australia & New Zealand, Bahamas, Bermuda, the Caribbean, the Panama Canal, U.S Eastern Seaboard, Hawaii, Indian Ocean, the Mediterranean, Mexico, Middle East, The Orient, the U.S Westcoast, and more.

Royal Caribbean International operates one of the most expansive global networks in the cruise industry, with ships sailing to over 270 destinations across six continents. Their "bread and butter" is the Caribbean and Bahamas, where they operate year-round out of major Florida hubs like Miami, Port Canaveral, and Fort Lauderdale, as well as Galveston, Texas. These routes often include a stop at their private island, "Perfect Day at CocoCay." In the summer months, a large portion of the fleet migrates to Europe, offering Mediterranean cruises (Italy, Greece, Spain, France) and Northern European itineraries (the Norwegian Fjords and the British Isles). They also have a massive presence in Alaska, with seasonal sailings from Seattle and Vancouver. Beyond these core regions, Royal Caribbean offers "bucket list" itineraries to the South Pacific (Australia and New Zealand), Asia (Japan, Singapore, and Thailand), and even the Mexican Riviera from Los Angeles. For the ultimate traveler, they also operate "Ultimate World Cruises" that span over 270 nights and visit dozens of countries across the globe in a single voyage.