Murren and Grindelwald are two small, car free villages that are often offered as good suggestions for where to base yourself in Switzerland.
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Luzern is more comfortable, old money and beautiful setting on the lake. Interlaken is closer to the big mountains, hiking, etc. I prefer Interlaken, but Luzern is more comfortable for first time to Switzerland. I would not want to spend 4 hours on the train to commute from one to the other however.
The choice is yours! Interlaken is more like a transport hub and it's also a larger town so it has more choices of shops and restaurants just to browse. Grindelwald is a scenic village (still with enough restaurants and some shopping) that is much more scenic than Interlaken.
You will obviously have come to the area to see the magnificent mountain scenery...so stay in Lauterbrunnen where you will actually be in the middle of it all. Interlaken is not in the Alps and is best used as a transport hub. If you should get bored, which you won't, then Interlaken is only a 2 minute train ride away.
Absorb the sweeping vistas and fresh mountain air of the Swiss Alps on an independent day-trip from Lucerne. Travel by comfortable coach through the UNESCO-listed Jungfrau region and admire scenery as you approach the mountain towns of Interlaken and Grindelwald.
Most visitors tend to spend more time in Interlaken than Lucerne because of the overall number of sights and activities. Usually, 1-3 days is a good amount of time for Lucerne, and 2-5 days is enough time in Interlaken. Families should spend more time in Interlaken than Lucerne.
You could certainly use Lucerne as a home base for exploring that part of Switzerland. However the travel time to and from the BernerOberland is a minimum of ~2H:20M each way, so that doesn't allow much time for enjoying the spectacular beauty of that area.
The central Old Town area is compact and can get crowded, but it's easy to lose the herd by venturing out a little to see the famous Lion of Lucerne or walk the Musegg Wall, with its series of watchtowers. All the major sites are walkable.
June to August: The best time to visit Interlaken is during the summer, from June to September. The temperature lingers around a pleasant 18°C to 20°C. It is the perfect time for aimless walks, trekking, mountaineering and adventure activities.