The Empathy Suite, which encompasses the top two levels of the Palms Casino Resort in Las Vegas, was designed by UK avant-garde artist Damien Hirst. His artwork alone in the 9,156-square-foot penthouse has been valued between $36 million and $39 million.

In 2026, the title for the most expensive hotel stay in the world belongs to the Lover's Deep Luxury Submarine in St. Lucia, which costs approximately $150,000 to $230,000 per night. This is not a traditional hotel room but a private, mobile submarine designed for ultimate romantic seclusion beneath the Caribbean Sea. The experience includes a personal captain, a private chef, and a butler, with views of vibrant marine life and shipwrecks directly from your bedroom. For those preferring land-based luxury, the Empathy Suite at the Palms Casino Resort in Las Vegas remains a top contender at $100,000 per night, featuring original artwork by Damien Hirst and a private cantilevered pool. Another major 2026 entry is the Royal Mansion Suite at Atlantis The Royal in Dubai, also priced at roughly $100,000 per night, offering massive multi-level living spaces and private infinity pools overlooking the Arabian Gulf. These accommodations cater to ultra-high-net-worth individuals who prioritize total privacy, bespoke service, and one-of-a-kind architectural or environmental settings.