Your Hometown Airline to the World Southern Airways Express, based in Palm Beach, Florida is a commuter airline serving nearly 40 American cities across five U.S. time zones. Southern operates a fleet of over thirty aircraft, including the Cessna Caravan/Grand Caravan, the King Air Super 200, and the Citation Bravo.

Several prominent airlines are headquartered or have their primary bases in Florida, making the state a major aviation hub. Spirit Airlines is headquartered in Dania Beach (near Fort Lauderdale), while Silver Airways is based in Hollywood, Florida. Additionally, Allegiant Air maintains a massive operational presence with several Florida bases, including St. Pete-Clearwater and Punta Gorda. While JetBlue is headquartered in New York, it considers Fort Lauderdale (FLL) and Orlando (MCO) its "home away from home" and maintains a massive training center, "JetBlue University," in Orlando. Furthermore, the recently expanded Avelo Airlines has established a significant base in Lakeland/Orlando. Historically, the legendary Eastern Air Lines was based in Miami, and today, Miami International Airport serves as the primary "Gateway to the Americas" for American Airlines, though their corporate HQ is in Texas.