Amadeus delivers NDC content from 19 airlines as a part of their Enterprise subscription meant for large travel players. This includes American Airlines, United, Singapore Airlines, Air France-KLM, Qantas, Qatar Airways, British Airways, Lufthansa, Finnair, and others, with more integrations in the queue.

Amadeus is the world's leading Global Distribution System (GDS), and in 2026, it serves as the backbone for over 400 major airlines. The list includes nearly all members of the Star Alliance, Oneworld, and SkyTeam networks. Key users include Lufthansa, Air France-KLM, British Airways, Qantas, Qatar Airways, and Singapore Airlines. These carriers use the Amadeus "Altea" suite to manage everything from seat bookings and check-ins to frequent flyer data. In North America, United Airlines and Air Canada are prominent users. In 2026, the system has evolved to support NDC (New Distribution Capability), allowing these airlines to offer personalized bundles and dynamic pricing directly to travel agents. Even low-cost carriers like Ryanair and EasyJet now have "Light" integrations with Amadeus to capture the lucrative corporate travel market, proving that almost every major player in the sky relies on this European-based tech giant to keep their passenger service systems running.