Generally, the safest lane is the one nearest the shoulder of the road. Driving in the slowest lane reduces the risk of being struck in a head-on crash by oncoming traffic.
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If a car is struck rear-ended (struck from behind), the safest seat may be the front passenger seat. If a vehicle is struck head-on, the safest seat may be the middle seat in the back seat.
I-95. According to NHTSA's data, I-95 is the most dangerous highway in the United States. In 2019, it had the highest number of overall fatalities (284) and fatalities per 100 miles (14.88). Many of these accidents occurred in the northeast in the winter, when road conditions were far from ideal.
Avoid the fast lane, which is where most highway accidents occur. If you're in the center lane, you have more escape alternatives if someone on the road appears to be about to cause an issue. In addition, if you're driving in the left lane, the highway patrol is more likely to keep a closer check on you.
The safest position in a vehicle is to sit upright, with feet on the floor, like you would in a chair, with a seat belt fastened. Airbags function with the assumption that passengers are sitting upright.