For most travelers in 2026, the best part of Tokyo to stay in is Shinjuku or the Tokyo Station/Marunouchi area. Shinjuku is the ultimate "all-rounder" because it sits on the Yamanote Loop Line, providing direct access to almost every major district. It offers a massive range of hotels from budget to luxury and features the world's busiest train station, making it perfect for those who want nightlife, shopping, and easy transport. For a more sophisticated, "quiet luxury" experience, the area around Tokyo Station is ideal; it is the hub for Shinkansen (bullet trains), making it perfect for those planning day trips to Kyoto or Hakone. If you are looking for a "trendy" vibe, Shibuya is the winner, while Asakusa is the best choice for those seeking a more traditional, "Old Tokyo" feel near the Senso-ji Temple. The "best" choice really depends on your priority: Shinjuku for convenience, Marunouchi for luxury/transit, or Asakusa for culture and lower-cost "ryokan" style accommodations.