Wide-body airplanes include the Airbus A330, Airbus A340, Airbus A350, Airbus A380, Boeing 747, Boeing 767, Boeing 777 and Boeing 787. Airlines are required to provide onboard aisle chairs on aircraft with an accessible lavatory.

Under current 2026 aviation regulations, all "wide-body" (twin-aisle) aircraft are required by law to have at least one wheelchair-accessible bathroom. This includes popular long-haul models such as the Boeing 777, 787 Dreamliner, and 747, as well as the Airbus A330, A350, and A380. These accessible lavatories are designed with collapsing walls or extra-wide doors that allow an "aisle chair" (a narrow wheelchair provided by the airline) to be pushed directly inside. On smaller "narrow-body" (single-aisle) planes like the Boeing 737 or Airbus A320, accessible bathrooms are not yet legally mandated, although many newer models (like the A321LR) are now being equipped with "Space-Flex" lavatories that can be converted for accessibility. For travelers with reduced mobility, it is a "pro" tip to call the airline 48 hours in advance to confirm that an "aisle chair" will be onboard, even on wide-body jets. While flight attendants can assist you to the bathroom door using the chair, they are not permitted to assist with transfers or personal care once inside, so traveling with a companion is recommended for those who cannot manage the lateral transfer independently.