Florence lies along the Arno River, with most tourist sights located north of the river. South of the Arno, between the river and the hills, the Oltrarno neighborhoods offer the best value hotels, though good rates can also be found near the train station in Santa Maria Novella.

For most travelers in 2026, the choice is between the Centro Storico (historic center) on the north side of the Arno and the Oltrarno on the south side. The Centro Storico is home to the Duomo, the Uffizi Gallery, and major shopping streets; it is best for first-time visitors who want to be steps away from the most famous landmarks. However, it can be very crowded and noisy. The Oltrarno (literally "the other side of the Arno") is often considered the "cooler," more authentic side of Florence. It is home to the Pitti Palace, the Boboli Gardens, and the trendy Santo Spirito neighborhood. Staying in the Oltrarno offers a more residential feel with artisan workshops, local wine bars, and generally lower prices for accommodations. Many frequent visitors prefer the Oltrarno because it allows them to escape the daytime tourist swarms while still being only a 10-to-15-minute walk from the main sites via the Ponte Vecchio. If you want luxury and convenience, stay in the Centro Storico; if you want local charm, craft boutiques, and a vibrant evening "piazza life," the Oltrarno is the better choice.