Sitting on a plane makes you tired due to a combination of low oxygen levels, dehydration, and "mental fatigue" from constant low-frequency noise. Even though the cabin is pressurized, the air inside an airplane at cruising altitude is equivalent to the air at 6,000 to 8,000 feet above sea level. This leads to slightly lower oxygen saturation in your blood, making you feel sluggish and sleepy. Furthermore, the humidity in a plane is typically below 10%—drier than most deserts—which causes rapid dehydration and headaches, both of which mimic the symptoms of exhaustion. The constant "white noise" of the jet engines also forces your brain to work harder to filter out the sound, a process that is surprisingly draining over several hours. Finally, the "forced immobility" of being stuck in a small seat slows down your circulation, which can lead to a drop in energy levels. This "travel fatigue" is distinct from jet lag (which is a disruption of your internal clock) and is why even a short, two-hour flight can leave you feeling like you've done a full day of manual labor.