Will Benadryl help me sleep on a plane?

If you're nervous about the idea of prescription sleep aids, plenty of over-the-counter options await. A diphenhydramine tablet or two (i.e., Benadryl or Zzzquil) is enough to make most people drowsy, as is a single dose of cough medicine containing diphenhydramine and doxylamine succinate (a.k.a. Nyquil).



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As a general precaution, however, Dr. Varga does not recommend taking either melatonin or a sleeping pill for the first time on a plane, given that both may occasionally cause adverse effects in some people. (And it's best not to find out that you're one of those people while you're trapped at 30,000 feet.)

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Yes, Benadryl is an antihistamine that causes drowsiness in most people. Some people use Benadryl for this side effect if they have trouble sleeping (insomnia), but this is not recommended long-term. The drowsy or sedation effect typically lasts about 8 hours, but may persist into the next day if taken at night.

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These drugs are usually taken shortly before a flight. They include: Anti-anxiety medication, such as diazepam (Valium) or alprazolam (Xanax). Motion sickness medication, such as dimenhydrinate (Dramamine).

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I recommend melatonin as a natural supplement to my patients with flight-related anxiety. Melatonin induces sleep and adjusts your circadian clock to help you function better when you reach your destination.

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Does Benadryl Help Anxiety? Although some people say that Benadryl helps their anxiety, it is not approved by the FDA for anxiety symptoms. Therefore, do not take it for anxiety unless your healthcare provider specifically recommends it. The only FDA-approved antihistamine for anxiety is hydroxyzine (Atarax, Vistaril).

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Read on for our science-backed strategies* for how to sleep on a plane.
  1. Stay at the right temperature. ...
  2. Wear bed socks. ...
  3. Power down your devices. ...
  4. Wear a light-blocking eye mask. ...
  5. Listen to pink noise. ...
  6. Wear noise-canceling headphones or earplugs. ...
  7. Uncross legs and use footrests. ...
  8. Lean backward with proper support.


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“As this hormone usually helps us fall and stay asleep, the excessively bright lights on airplanes naturally make it hard to sleep well.” Even if the lights aren't bright enough to suppress melatonin, they can distract and irritate those trying to sleep.

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Usually, most airlines will rebook you on the next flight, and that too for free. Although, you might have to fly on standby depending on seat availability. Some airlines, in fact, automatically rebook you.

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Usually, most airlines will rebook you on the next flight, and that too for free. Although, you might have to fly on standby depending on seat availability. Some airlines, in fact, automatically rebook you.

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Pharmacological treatment Medication is sometimes prescribed on a temporary basis to treat the symptoms of a flying phobia, such as anxiety and nausea. These drugs are usually taken shortly before a flight. They include: Anti-anxiety medication, such as diazepam (Valium) or alprazolam (Xanax).

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1) Diazepam is a sedative, which means it makes you sleepy and more relaxed.

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The best thing you can do to prevent jet lag is to get a lot of sleep the night before your flight. If you board the plane sleep deprived, you're less likely to fall asleep when you want to on the flight, and less likely to stay asleep. Not getting enough rest before a trip starts you at a disadvantage already.

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The best thing you can do to prevent jet lag is to get a lot of sleep the night before your flight. If you board the plane sleep deprived, you're less likely to fall asleep when you want to on the flight, and less likely to stay asleep. Not getting enough rest before a trip starts you at a disadvantage already.

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Get into the habit of sleeping eight hours per night. When needed, and if possible, nap during the day, but limit the nap to less than 30 minutes.

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Take melatonin 20 to 30 minutes before sleep (for eastward travel, melatonin can also be taken en route, 30 minutes prior to the target bedtime at your destination. It doesn't need to be taken en route for westward travel).

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Here are my tips for avoiding and, if need be, surviving the dreaded middle seat on your next flight.
  1. Make a narrow escape. ...
  2. Politely assume priority placement on the armrests. ...
  3. 2-3-2 beats 3-3. ...
  4. Go before you go. ...
  5. Beat feet before they start sawing wood. ...
  6. Look both ways. ...
  7. Use sleep and comfort aids. ...
  8. Hide in plain sight.


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Dramamine is an over-the-counter preventative drug that can help with motion sickness while flying. Although this medication can cause severe drowsiness, it can help you sleep through your flight instead of feeling the unfortunate common symptoms.

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