Benadryl can be highly effective in mitigating issues with environmental allergies. Still, if your dog is struggling with breathing, Benadryl will not be as effective, and you should seek immediate advice from your veterinarian.
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Benadryl®may make some dogs a little sleepy and less responsive, but it doesn't do anything for their underlying anxiety. Benadryl® does has some efficacy in the prevention of motion sickness in dogs. So, if your dog is anxious because they're nauseous in the car, it could help.