Travelers to sub-Saharan Africa have the greatest risk of both getting malaria and dying from their infection. However, all travelers to countries where malaria is present may be at risk for infection.
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Exercise increased caution in South Africa due to crime and civil unrest. Country Summary: Violent crime, such as armed robbery, rape, carjacking, mugging, and smash-and-grab attacks on vehicles, is common. There is a higher risk of violent crime in the central business districts of major cities after dark.
Nigeria, the Democratic Republic of the Congo, the United Republic of Tanzania, and Niger account for about half of all such fatalities. Nigeria alone had 31.3% of the world's malaria deaths in 2021. Malaria is transmitted through mosquitoes infected with plasmodium, a single-cell parasite.
Cape Town is not a malaria area. You don't need to worry about malaria tablets unless you are travelling from Cape Town to high-risk parts of the country. There is also a standard list of vaccinations that many countries recommend before travelling abroad that includes rabies, typhoid, and tetanus.