Are antihistamines allowed on planes?

For cetirizine (Zyrtec®) and levocetirizine (Xyzal®), you should not fly for 48 hours after taking the last dose. For diphenhydramine or doxylamine, you should not fly for 60 hours after taking the last dose.



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If you aren't sure whether your medication falls into one of these categories, you should check with your AME:
  • Tranquilizers, such as but not limited to Valium, Librium, Ativan.
  • Most antidepressants. ...
  • Opiates, such as Morphine, Codeine, Lortab, Percodan, Oxycontin.
  • Muscle relaxants, such as Soma, Sonata, Flexeril.


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If you have any allergy or cold-related symptoms, make sure you take an antihistamine or decongestant spray at least 30-45 minutes before your flight. Following this method can help alleviate any additional sinus pressure.

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At the Airport Security Checkpoint You can tell the screening officer about your prescription drugs or present a written list. You may wish to bring doctor's notes, original prescription bottles or containers, and other documentation to make the screening process go more quickly.

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Yes, you can bring medications on a plane. But traveling with medicines requires extra planning. Medications may need additional screening in airport security. However, passengers should be able to bring all prescribed medicines and medical supplies onto the airplane.

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Medications can be packed in a pill box. However, it is usually best to keep medicines in labeled containers provided by your pharmacist. TSA does not require medications to be in their original, labeled, prescription containers. However, using the original containers may limit delays or additional questioning.

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Try taking a decongestant or a nonsteroidal anti-inflammatory medicine before you get on the airplane, particularly if you are suffering from a head cold or swollen sinuses. If you have high blood pressure or heart problems, you should not take decongestants without approval of your healthcare provider.

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The most frequently used antihistamines to treat motion sickness include cyclizine, dimenhydrinate, meclizine, and promethazine (oral and suppository); nonsedating antihistamines appear to be less effective.

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You may bring medically necessary liquids, medications and creams in excess of 3.4 ounces or 100 milliliters in your carry-on bag. Remove them from your carry-on bag to be screened separately from the rest of your belongings.

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Firearms, ammunition, and fireworks are prohibited, as are all knives and safety razors (including pocket knives and Swiss Army knives). Straight razors and replacement blades for straight razors are also not allowed. Most tools also cannot be packed in carry-on luggage, as they have the potential to cause harm.

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You may place medications in 3.4 ounce (100 milliliters) or smaller containers in a one-quart size clear zip-top plastic bag along with your other personal liquid and gel items. If your prescription medications come in larger containers or bottles, you will need to pack them separately in your carry-on bag.

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The TSA does not require you to have your medication in its original prescription bottle, so traveling with a pill case does not violate any rules. You will also generally not have to tell the officers about your medication unless it is a liquid.

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Benadryl - Many parents ask about giving Benadryl to their child before a flight to promote rest and sleep. This is not necessary. Benadryl does not necessarily cause a child to sleep or sit quietly. In fact, it may cause a child to be hyper and/or irritable.

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If you are suffering from a cold or allergies at the time of air travel, you may want to consider antihistamines or decongestants to help you avoid ear pair during your travels.

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