The biggest offender is the Mediterranean, which tends to be roughest in the fall and winter, due to winds and storms. However, avid cruisers have experienced rough seas in the spring and summer, so be prepared for anything.
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Motion sickness is least likely on larger ships and when you're moving slowly in calm waters, for example in the Alaskan straits, Norwegian fjords, or along the Mediterranean coast. The Caribbean is generally placid, except during hurricane season, which typically runs from June through November.
Definitely not all the same. Also depends on season, and luck. Alaska is super calm though, followed by probably the Mediterranean. Leaving out of Florida to the bahamas can get seriously rough, and so can cruising down the coast from up north.
The side that your ship docks into port will vary depending on such factors as weather conditions and how busy the port is on that particular day. There is no real concern for cabin position on Mediterranean cruise unless you have an individual preference or are looking to see something specific.
To minimize the risk of seasickness, book one of the world's largest ships, such as Royal Caribbean's Wonder of the Seas. Keep in mind that the ocean is much larger than even the most gargantuan ships, so when the seas are rough, you can still feel movement — just less than if you're sailing on a 100-person yacht.
If you're worried about seasickness, pick a cabin that's as close to the water level as possible and in the center of the ship. You'll be at the ship's fulcrum point, which means you'll feel less movement than people on higher decks with cabins far forward or all the way at the back.
Cabin ChoiceThe lower you are, and more towards the middle of the ship, you will not feel it as much. Cabins at the front and back of the ship tend to sway the most, so you want to avoid any rooms in these areas.
Generally, guests will experience rolling, but that is usually the extent of it. When it comes to rough seas on a cruise ship, these massive vessels are well equipped to handle anything nature can throw at them.
Instead, if you want to avoid motion sickness, aim to book a stateroom set as close to the center of the ship as possible, on a lower deck, where you're guaranteed the smoothest ride and most stability in the case of turbulent seas.