The simple answer is no. The Airbus philosophy is to have as much commonality across their aircraft as possible to facilitate easier crew training at a reduced cost when changing type.

While both are made by Airbus, an A320 pilot cannot immediately fly an A220 without a new Type Rating. Unlike the "Cross-Crew Qualification" (CCQ) that allows pilots to transition quickly between the A320, A330, and A350 due to their identical cockpit philosophies and fly-by-wire logic, the A220 (originally the Bombardier CSeries) has a completely different design. Its flight deck, avionics, and flight control laws are distinct from the "classic" Airbus family. In 2026, an A320 pilot must undergo a full transition course, which typically includes several weeks of ground school and extensive Full Flight Simulator (FFS) sessions to master the A220’s unique systems. Although Airbus has worked to harmonize some procedures, the two aircraft are not "type-compatible" in the way a Boeing 757 and 767 are. Therefore, an airline cannot simply swap a pilot from an A320 to an A220 for a single flight; the pilot must be specifically licensed and "current" on the A220 model to legally operate it.