Absolutely! A day trip from Milan to Switzerland is very feasible and popular due to the high-speed rail links. The most common destination is Lugano, which is only about 1 hour and 15 minutes away via direct EuroCity (EC) trains from Milano Centrale. For a more scenic "Alpine" experience, many travelers take a train to Tirano and board the world-famous Bernina Express, which reaches the high mountain passes of St. Moritz. Another option is a trip to Lucerne, which takes about 3 to 4 hours each way, though this makes for a very long day. In 2026, it is essential to carry your passport, as you will be crossing an international border, and although Switzerland is in the Schengen Area, random customs checks are common.