Yes, you can effectively use Capital One miles on virtually any airline through two primary methods. First, you can use the "Purchase Eraser" feature, which allows you to book a flight on any airline's website using your Venture or Spark card and then use your miles to "pay yourself back" for the travel purchase at a rate of 1 cent per mile. Second, you can book directly through the Capital One Travel portal, which functions like an online travel agency. For the highest value, however, Capital One allows you to transfer miles to over 15+ partner loyalty programs, including British Airways, Air Canada (Aeroplan), and Avianca. While you cannot "transfer" directly to a domestic carrier like Delta or United, you can use partner transfers (e.g., transferring to Virgin Red to book a Delta flight) to fly on almost any carrier globally. This flexibility makes Capital One miles one of the most versatile "transferable currencies" available in the travel rewards market today.