Yes, Capital One rewards are highly versatile and can be used on virtually any airline through two main methods. First, you can use the "Cover Your Travel Purchases" feature, which allows you to book a flight with any airline or travel site using your card and then "erase" the charge from your statement using miles at a 1 cent per mile rate. Second, for greater potential value, you can transfer your miles to over 15 leading travel loyalty programs, including airline partners like Air France-KLM (Flying Blue), British Airways, Emirates, and Turkish Airlines. While you cannot transfer miles directly to "The Big Three" US carriers (Delta, United, American), you can often use partner transfers to book their flights—for example, transferring to British Airways to book an American Airlines flight.