You cannot "directly" pay with Chase Ultimate Rewards points on the Expedia website as a integrated checkout option (unlike Amazon). However, there is a standard workaround: you can book your travel on Expedia using your eligible Chase credit card and then use the "Statement Credit" or "Pay Yourself Back" feature in the Chase portal to wipe out the charge with your points. Alternatively, many travelers find that the Chase Travel℠ portal (powered by Expedia technology) offers the same inventory and user-friendly interface as Expedia. When you book through the Chase portal, you can use your points at a value of 1 to 1.5 cents per point (depending on whether you have the Sapphire Preferred or Reserve card). If you have a specific Expedia-only deal, your best bet is to pay cash and redeem points for a statement credit at 1 cent per point, though this is generally less "valuable" than booking directly through the Chase portal where your points have a boosted redemption rate.