Yes, you can use the Japan Rail (JR) Pass to travel from Osaka to Tokyo, but there are specific rules regarding which trains you can board. The journey is made via the Tokaido Shinkansen line. If you have a standard JR Pass, you can ride the Hikari or Kodama trains for free. However, if you wish to take the Nozomi—the fastest and most frequent service—you must pay a supplemental "Nozomi/Mizuho" upgrade fee, which was introduced following the 2023 price hike. Without this supplement, the Nozomi is not covered. The Hikari takes approximately 2 hours and 53 minutes, whereas the Nozomi takes about 2 hours and 30 minutes. You must also remember to reserve your seat in advance at a JR ticket office or a kiosk, as "oversized baggage" (suitcases with a total dimension over 160cm) requires a specific seat reservation in the back row of the car to avoid a fine. The pass also covers local JR lines within both cities, such as the Osaka Loop Line or the Yamanote Line in Tokyo.