Yes, you can do a day trip from Rome to the Amalfi Coast, but it is a very long and logistically intense day. In 2026, the most efficient "DIY" route is to take a high-speed Frecciarossa train from Rome to Salerno (approx. 2 hours), and then board a ferry (Travelmar) from Salerno to Amalfi or Positano. This allows you to avoid the legendary Amalfi Drive traffic and see the coastline from the water. Alternatively, many travelers book a guided coach tour that handles all the transportation and usually includes stops in Positano and Amalfi. Expect to spend about 5 to 6 hours of the day just in transit. While it is "possible" to see the "glamour" spots in a single day, many travel experts advise against it, suggesting that you will spend more time looking out of windows than on the ground. A better "one-day" alternative is often a high-speed train to Naples followed by a 45-minute ferry to the island of Capri, which is more compact and easier to navigate on a tight schedule.