Yes, you can drive a rental car from Germany to Prague (Czech Republic), but you must notify the rental company in advance. Many premium German rental brands (like Sixt, Hertz, or Europcar) have specific restrictions on "high-end" vehicles (like BMW, Mercedes-Benz, or Audi) crossing into Eastern European countries due to higher theft risks. While they will allow a Volkswagen or a Skoda to make the trip, they may require an additional "Cross-Border Fee" (usually €30–€60) to cover extended insurance. Once you cross the border into the Czech Republic, you must purchase a digital motorway vignette (toll pass), which you can buy online or at gas stations near the border; failing to have one can result in a heavy fine. Additionally, ensure the car has a "Green Card" insurance document and the mandatory safety kit (high-vis vest, warning triangle). Driving from Munich or Berlin to Prague is a popular scenic route in 2026, taking about 4 to 5 hours, but ignoring the rental company's cross-border policy can void your insurance entirely in the event of an accident.