Yes, you can generally rent a car in Germany and drive it to Italy in 2026, but it is subject to "Cross-Border" policies and potential fees. Most major agencies like Sixt, Enterprise, and Europcar allow travel into "Zone 1" countries (which includes Italy), but you must declare this at the time of booking. There is often a cross-border fee (roughly €5 to €10 per day, capped at €50). Crucially, there are restrictions on luxury vehicles: brands like BMW, Mercedes, and Audi, or high-end SUVs, are often prohibited from being taken into Italy (or specifically Southern Italy) due to higher theft rates. Additionally, you must ensure the car has the necessary equipment for Italian roads, such as a high-visibility vest for every passenger, and you should obtain an International Driving Permit (IDP) to accompany your standard license, as it is technically a legal requirement in Italy.