Yes, you can generally take a rental car from Germany to Prague (Czech Republic), but it is not an automatic permission and usually involves a specific "Cross-Border Fee." Major rental companies like Sixt, Europcar, Hertz, and Avis allow travel from Germany into the Czech Republic, but they often restrict which types of cars can make the journey. Due to higher theft rates in Eastern Europe, luxury brands like BMW, Mercedes-Benz, Audi, and VW Touareg are often strictly prohibited from crossing the border into Prague, even if you are renting from a premium location in Munich or Dresden. When booking in 2026, you must explicitly inform the rental agency of your intent to cross the border so they can provide the necessary insurance documentation (Green Card) and charge the required fee (typically €30–€50). Additionally, you must purchase a Czech Highway Vignette (toll pass) at the border or online, as German rental cars will not have one. Failure to disclose the cross-border trip can void your insurance entirely, leaving you personally liable for the full value of the vehicle if an accident or theft occurs while the car is in the Czech Republic.