While you can physically wear just one flight sock, it is a peer-recommended "fail" for effective medical prevention. Flight socks (compression stockings) work by applying consistent pressure to the lower legs to maintain blood flow and reduce the risk of Deep Vein Thrombosis (DVT) during long periods of inactivity. If you only wear one, you are only protecting one leg, leaving the other vulnerable to swelling and potential blood clots. DVT doesn't "pick a side" based on your preference, and the physiological triggers—dehydration, low cabin pressure, and cramped seating—affect both limbs equally. For a high-value safety strategy, you should always wear the pair as intended. If you find them uncomfortable, ensure you have the correct size and compression level (usually 15-20 mmHg for travel). A peer-to-peer tip for 2026: if you have a specific injury on one leg that prevents you from wearing a sock, consult a doctor about alternative anticoagulants rather than relying on a single stocking, which provides zero protection for the "naked" leg.