Does flying cause brain inflammation?

At high altitudes, cerebral hypoxia triggers the upregulation of VEGF. In turn, the VEGF increases capillary permeability and contributes to cerebral edema. Note, however, that brain swelling attributable to ascent to high altitudes may occur without any associated symptoms.



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“At oxygen levels equivalent to altitudes above 12,000ft (3.6km), healthy adults can start to show measurable changes in their memory, their ability to perform calculations and make decisions,” BBC had reported earlier.

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The air pressure on board is therefore almost 19% lower. Accordingly, the cerebral oedema will expand, not in the same proportion, since the human body is itself a kind of pressure suit, but a few millimetres is enough to increase the pressure in the brain to the extent that it becomes life-threatening.

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The simulation with this model suggested that intracranial air volumes above 11 ml could result in intracranial hypertension during the drop in cabin pressure [5]. Moreover, the increase in ICP was also found to depend on the rate of change in cabin pressure [2, 5].

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Answer From Sheldon G. Sheps, M.D. Leg and foot swelling during air travel is common and typically harmless. The most likely culprit is inactivity during a flight.

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Post-flight recovery
  1. Elevate your feet. If you're uncomfortable, grab a seat at the arrival gate where you can elevate your feet. ...
  2. Soak your feet or take a bath when you arrive at your accommodations. Just as a hot tub or jacuzzi increases blood flow, a hot bath can have the same effect. ...
  3. Take a walk or exercise.


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The effects of flying on the human body vary from mild skin dryness to more severe problems like deafness. Flying increases the risk of catching a cold, dehydration, aging faster, reduced alertness, increased risk of diseases like cancer, fuzzy thinking, and many others.

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It is well known that imbalance between atmospheric pressure changes and pressure inside the sinuses can cause tissue damage [43–45]. This means, for example, that the pressure in the sinuses is lower than the cabin pressure during the landing [6, 26]. At take-off, the cabin pressure is lower than the sinuses [6, 26].

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Plane travel makes jet lag worse because your body moves much faster than your brain and circadian rhythms can process the time change. Other aspects of travel can also contribute to jet lag and may make symptoms worse: Long periods of sitting on a plane. Lack of oxygen and decreased air pressure in the airplane cabin.

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Who should not travel by air? Diseases that prevent you from boarding a plane
  • Chronic obstructive pulmonary disease (COPD)
  • A recent stroke.
  • Infectious diseases, such as chickenpox, influenza or even COVID-19.
  • A recent surgery.
  • A pregnancy of over 28 weeks.
  • Angina (chest pain at rest)


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The amount of radiation is minuscule, and jet lag can usually be overcome in a few days. But for anyone flying dozens of times per year — say, at least two cross-country flights per month — these stresses start to add up, putting frequent fliers in higher risk categories for cancers and other chronic health issues.

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If your blood pressure is higher than 120 over 80, seek medical advice before you travel.

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