Doing your pre-start scan, the temperature controller for the cargo holds is usually just left at 12 o'clock. That should result in a zone temperature of about 15C.
The first question that arises is whether a commercial cargo plane is pressurised. If asked in one word, it's yes. Most commercial air freighters predominantly use pressurised fleets. The majority of cargo that is shipped requires temperature and pressure controls.
That being said, most flight crew will have considerably higher tolerance for turbulence than most passengers, and crews flying freighters are considerably more likely to just ignore some light turbulence than crews flying passengers (the boxes* neither shriek, nor write nasty letters to the airline).
They usually have a large and empty fuselage, with no seats, windows, or amenities for passengers. However, some cargo airplanes may have a small and separate cabin for the crew and a few authorized passengers, such as pilots, mechanics, security personnel, or cargo handlers.
Typically, cargo fire suppression systems have an initial high-rate knockdown discharge, followed by a low-rate metered discharge of Halon 1301, designed to keep the fire suppressed for continued safe flight and landing at the nearest suitable airport. Halon can be discharged into the forward or aft cargo compartment.
According to estimates released by the Department of Transportation, less than 1 in 10,000 animals were injured, lost, or killed from flying. That said, the general safety of flying your pet as cargo doesn't discount the gravity of the fact that animals are sometimes harmed by flying in the cargo hold.
Shipping cargo by plane can be an efficient, safe, and quick way to move goods but there are some risks to be aware of, including human error, extreme weather, turbulence, cargo fires, and shipping hazardous materials.
The total crew of the cargo flights usually consists of two pilots: a Captain and a First Officer.On longer flights we are with three or four pilots: besides the standard crew also a Second Officer and/or sometimes another Captain or First Officer.
Cargo operators use passenger airports as well. Night flights for passengers aren't popular for a variety of reasons. Which means there are less flights for passengers landing and taking off during the night hours freeing up slots for cargo.