Carrying medication on a plane requires adherence to TSA and international "3-1-1" rules, but there are significant exemptions for health needs. You should keep all medications in your carry-on bag rather than checked luggage to avoid issues if your bag is lost or exposed to extreme temperatures in the hold. While not legally required for domestic flights, it is highly recommended to keep pills in their original pharmacy-labeled containers to avoid questioning by security. Liquid medications, even if they exceed the 3.4 oz (100ml) limit, are permitted; you must simply declare them to the TSA officer at the start of the screening process. You do not need to keep liquid meds in a zip-top bag. For refrigerated meds like insulin, you can use a small cooler bag with frozen gel packs, which are also exempt from liquid rules. Always carry a copy of your prescription or a doctor’s note, especially when traveling internationally, as some countries have very strict laws regarding "controlled substances" like Adderall or strong painkillers.