The metro doesn't run that early so you will need to either use a private transfer company or book a taxi. The fixed rate for a taxi is 48 euros to FCO.

Getting to Rome Fiumicino Airport (FCO) for a 6am flight in 2026 requires careful planning, as the Leonardo Express train doesn't start running until around 5:00 AM. For a 4am arrival, the most reliable and convenient option is to reserve a taxi or an Uber in advance. A flat-rate taxi from the city center costs approximately €50, while an Uber Reserve can range from €60 to €80 depending on the vehicle. For a budget-friendly alternative, several private bus companies like TerraVision and SIT Bus Shuttle operate night services from Termini Station, often with departures around 2:30 AM or 3:30 AM. Alternatively, the public Cotral night bus runs from the "Giovanni Giolitti" side of Termini and takes about 35–45 minutes at that hour since there is no traffic. If you prefer to avoid the stress of a commute, many travelers choose to stay their final night at the Hilton Rome Airport, which is connected to the terminals via a covered walkway, or the Hilton Garden Inn, which offers a 24/7 shuttle service to the departures area.