Tuscany and the Amalfi Coast are located in two different regions of Italy—Central and Southern—separated by roughly 520 to 560 kilometers (320 to 350 miles). In 2026, the travel time between the two depends heavily on your transport method. A direct drive from Florence (the heart of Tuscany) to Amalfi takes approximately 5.5 to 6 hours via the A1 Autostrada, though traffic near Naples can add significant delays. For most travelers in 2026, the high-speed Frecciarossa train is the preferred choice; you can travel from Florence to Salerno (the gateway to the Amalfi Coast) in about 4 hours and 30 minutes. From Salerno, you then take a ferry or a smaller bus to reach towns like Positano. Because the two regions offer such different vibes—rolling hills and vineyards versus dramatic seaside cliffs—they are often paired together in 10-day Italian "Grand Tour" itineraries.