The journey from Pisa Centrale to Firenze Santa Maria Novella is relatively short, but it is important to note that most of the 50+ daily departures are Regionale trains rather than dedicated "bullet" trains. In 2026, the fastest direct services take approximately 50 to 56 minutes, while the average regional train takes about 1 hour and 1 minute. While high-speed brands like Frecciargento occasionally operate on this corridor, they don't significantly cut the time because the distance is only 43 miles (69 km). Tickets for the regional trains are a flat, affordable rate (starting around €9.30) and do not require advance booking, making this one of the most popular and "stress-free" day trips in Tuscany. Always validate your paper ticket at the green machines on the platform before boarding to avoid a €50 fine from the conductor.