A total of 36 Business Class seats are laid out in a 1-2-1 configuration, with Rows 1-6 forming a forward section, and Rows 7-9 forming a mini-cabin behind it, separated by the lavatories.

The number of Business Class seats on a Qatar Airways Airbus A350 depends on the specific variant and cabin configuration. On the A350-1000, Qatar typically offers two configurations: a high-premium version with 46 Qsuite seats (spread across a main cabin and a quiet 10-seat mini-cabin) and a denser version with only 24 Qsuite seats. On the smaller A350-900, the most common configuration features 36 Business Class seats. It is important to note that while the A350-1000 is guaranteed to have the "Qsuite" (featuring sliding privacy doors and double-bed capabilities), some older A350-900 aircraft still feature the "Classic" Collins Super Diamond 1-2-1 reverse-herringbone seats. In 2026, travelers can easily distinguish which version they have by checking the seat map during booking; if the Business cabin ends at row 6, it is the 24-seat version, whereas extending to row 12 indicates the 46-seat flagship layout. All Qatar A350 Business Class cabins offer direct aisle access, 1-2-1 configuration, and fully flat beds.