To truly appreciate the breadth of Tuscany, you should spend a minimum of 7 to 10 days in the region. A well-balanced 2026 itinerary usually allocates 3 days in Florence to cover the Uffizi Gallery, the Duomo, and the Accademia, followed by 4 to 7 days in the countryside. For the rural portion, staying in a "base" like Siena, San Gimignano, or the Val d'Orcia allows for easy day trips to vineyards, truffle hunting, and thermal baths. If you only have 5 days, you will likely have to choose between a "city-centric" trip or a "countryside-only" escape. Ten days is the "magic number" because it allows for "slow travel"—giving you time to enjoy a long, unhurried lunch in a hilltop village without rushing to the next museum. Having a rental car is highly recommended for the countryside portion to access the hidden gems that the trains don't reach, while Florence itself is best navigated entirely on foot.