Aspirin? Taking 75mg (a quarter of a normal 300mg tablet) some hours before your flight may reduce your chances of a DVT slightly (but remember that Aspirin can sometimes cause indigestion in people with a tendency to it, if in doubt ask your GP);
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Your GP will not be able to advise on the use of anticoagulants for flying as it is a specialist issue, so allow plenty of time to get an opinion from your specialist. Note: aspirin is not used to prevent DVT.
The plasma half-life of aspirin is only 20 minutes; however, because platelets cannot generate new COX, the effects of aspirin last for the duration of the life of the platelet (˜10 days). After a single dose of aspirin, platelet COX activity recovers by ˜10% per day as a function of platelet turnover.
Move your legs frequently when on long trips and exercise your calf muscles to improve the flow of blood. If you've been sitting for a long time, take a break to stretch your legs. Extend your legs straight out and flex your ankles (pulling your toes toward you).
DVT or PE may manifest during or shortly after the flight, but often not for several weeks. Prevention includes choosing aisle seating, maintaining hydration, walking frequently, wearing loose clothing, exercising the lower extremities, using a foot rest, and avoiding alcohol and sleeping pills.
These drugs are usually taken shortly before a flight. They include: Anti-anxiety medication, such as diazepam (Valium) or alprazolam (Xanax). Motion sickness medication, such as dimenhydrinate (Dramamine).