How much Benadryl can I give my 40 pound dog?

When administering Benadryl to dogs, the general recommendation is to give 2 to 4 milligrams per kilogram of body weight, or 0.9 to 1.8 milligrams per pound of your dog's body weight 1-2 times per day. The effects of the medication typically last for around 6-8 hours.



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In living animals, hyperactivity, depression, hypersalivation, tachypnea, and tachycardia are the most common signs reported with ethanolamine-based antihistamines, usually occurring within 1 h of exposure (10). With overdose, dogs may also exhibit mydriasis, dry mucous membranes, disorientation, and fever (10).

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The effects of the medication typically last for around 6-8 hours. Liquid Benadryl is typically recommended for dogs weighing less than 10 pounds, as this can make it easier to achieve an accurate and appropriate dose.

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It usually takes Benadryl about 15 to 30 minutes to start working. The effects of Benadryl tend to last for 4 to 6 hours, but the medication can stick around in the body for much longer. Since Benadryl can make you sleepy, it can be best to take it in the evening.

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Yes, Benadryl is an antihistamine that causes drowsiness in most people. Some people use Benadryl for this side effect if they have trouble sleeping (insomnia), but this is not recommended long-term. The drowsy or sedation effect typically lasts about 8 hours, but may persist into the next day if taken at night.

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