What happens if I give my dog too much Benadryl?

In living animals, hyperactivity, depression, hypersalivation, tachypnea, and tachycardia are the most common signs reported with ethanolamine-based antihistamines, usually occurring within 1 h of exposure (10). With overdose, dogs may also exhibit mydriasis, dry mucous membranes, disorientation, and fever (10).



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When administering Benadryl to dogs, the general recommendation is to give 2 to 4 milligrams per kilogram of body weight, or 0.9 to 1.8 milligrams per pound of your dog's body weight 1-2 times per day. The effects of the medication typically last for around 6-8 hours.

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