For most healthy individuals, it is generally better to sleep with compression socks off. Compression garments are designed to help your circulatory system fight gravity while you are standing or sitting, pushing blood from the lower limbs back toward the heart. When you are lying flat in bed, gravity is no longer a factor, and your heart can circulate blood to your legs much more easily on its own. Wearing tight compression socks while horizontal can actually restrict blood flow in some cases and may cause skin irritation if worn 24/7. However, there are medical exceptions: patients with certain conditions like lymphedema, chronic venous insufficiency, or those recovering from specific surgeries may be instructed by their doctor to wear them at night. If you do wear them to bed, they should typically be a lower compression level (Class 1) than what you wear during the day. For the average traveler or athlete, taking them off at night allows the skin to breathe and the muscles to recover naturally.