Italy is generally safe at night, however, it is important to take the same precautions as you would in any other city.
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While particular areas have a negative reputation, the risk of violent crimes is very low. The majority of crime in Rome is petty crime such as pickpocketing, scams or theft. Even at night, Rome's a hub of social activity, and night buses get you home safely after you enjoy Rome's nightlife.
When it comes to the safety in Milan and Florence, both cities are considered to be safe. However, you should keep in mind that Milan's popularity with tourists means that there is a higher theft risk than in Florence. All in all, the final choice between moving to Milan or Florence is up to you.
Tourists and first-time travelers need not fear because Milan is a safe city to visit. It finished strong with a high overall score of 71.3 in The Economist's 2021 Safe Cities Index. One factor that makes Milan such a safe city is its low crime rates.