Yes, the ferry service between Plymouth and Santander is currently operational and is a key route for Brittany Ferries in 2026. This service typically runs during the "high season," which generally spans from March/April through October or November. The crossing is popular for travelers looking to reach Northern Spain while avoiding the long drive through France. The journey usually takes about 20 to 22 hours, often departing in the afternoon and arriving the following morning. Brittany Ferries has recently updated its fleet on this route with newer, more environmentally friendly "E-Flexer" class ships like the Galicia and Santander, which offer a cruise-like experience with high-end dining, lounges, and comfortable cabins. It is important to note that during the winter months, this specific route may be paused or reduced, with travelers being diverted to the year-round Portsmouth to Santander or Portsmouth to Bilbao services. Because this route is highly seasonal and caters heavily to holidaymakers, booking several months in advance is essential for securing a vehicle space or a specific cabin type.