For optimum protection, pilots are encouraged to use supplemental oxygen above 10,000 feet during the day, and above 5,000 feet at night.
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For Part 91 General Aviation operations the required flight crew must use supplemental oxygen for any portion of the flight that exceeds 30 minutes above a cabin pressure altitude of 12,500 feet mean sea level (MSL) up to and including 14,000 feet (MSL).
(ii) Above 15,000 feet MSL, oxygen to each occupant of the aircraft, other than the pilots, for one hour unless, at all times during flight above that altitude, the aircraft can safely descend to 15,000 feet MSL within four minutes, in which case only a 30-minute supply is required.
Lower levels of oxygen in your blood may make you feel unwell or could even be harmful to you during or after your flight. This means that, even if you do not usually need oxygen, you may need it while flying. Additional oxygen keeps the oxygen levels in your blood at a comfortable level and keeps you safe.
In aeronautics, hypoxia typically results from a decompression or lack of pressurisation of the aircraft cabin. Hypoxia occurs within a few minutes if the cabin pressure altitude rises to between 5,000-6,000 m (about 16,000 - 20,000 ft).
If you need oxygen in flight, you must take a portable oxygen concentrator with you, and , you must let your airline know ahead of time. They may require a doctor's letter to verify the need for the POC on the plane.
The Federal Aviation Administration (FAA) doesn't allow passengers to bring portable oxygen tanks or liquid oxygen on board, so if you require oxygen during a flight, you'll have to use a portable oxygen concentrator.