What drug relaxes you on a plane?

These drugs are usually taken shortly before a flight. They include: Anti-anxiety medication, such as diazepam (Valium) or alprazolam (Xanax). Motion sickness medication, such as dimenhydrinate (Dramamine).



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These drugs are usually taken shortly before a flight. They include: Anti-anxiety medication, such as diazepam (Valium) or alprazolam (Xanax). Motion sickness medication, such as dimenhydrinate (Dramamine).

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This article discusses some strategies for managing panic attacks on a plane, including:
  1. Taking medication for panic attacks.
  2. Using visualization.
  3. Practicing relaxation techniques.
  4. Finding healthy distractions.
  5. Taking classes to combat fear of flying.
  6. Seeking support from other fliers.
  7. Thinking realistically.


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People often come to us requesting the doctor or nurse to prescribe diazepam for fear of flying or assist with sleep during flights. Diazepam is a sedative, which means it makes you sleepy and more relaxed.

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While Xanax may be useful for flying on an airplane, it will not help you with your anxiety. It may help in the moment but you will not tackle your fear of flying if you are asleep the whole flight. If you ran out of your medication or left it at home, the anxiety will still exist if you go on an airplane again.

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1) Diazepam is a sedative, which means it makes you sleepy and more relaxed.

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I recommend melatonin as a natural supplement to my patients with flight-related anxiety. Melatonin induces sleep and adjusts your circadian clock to help you function better when you reach your destination.

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The two main medication classes most often prescribed are:
  • Benzodiazepines, such as the antianxiety drugs alprazolam (Xanax®), clonazepam (Klonopin®) and diazepam (Valium®).
  • Selective serotonin reuptake inhibitors, such as paroxetine (Paxil®) or escitalopram (Lexapro®).


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Also, if possible, travel with a supportive friend or relative. They can help you work through the anxiety, guide you through relaxation exercises, or simply keep you distracted. Your companion can also help manage details such as checking luggage, which you may feel uncomfortable handling.

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Over-the-counter options include Dramamine (bonus: it will also help if you have motion sickness), melatonin (a hormone that can help with sleep and prevent jet lag), any antihistamine containing diphenhydramine (such as Benadryl), and medicines designed for insomnia, like Unisom or ZzzQuil.

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Take melatonin. If you're traveling, your body might need a little nudge. Melatonin is available as a nonprescription sleep aid in doses of up to 10 milligrams. It helps your body produce natural melatonin at the appropriate time when your schedule is off-kilter.

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Travel anxiety is not an officially diagnosed mental health issue, but can be severe enough to interfere with people's daily lives. People with travel anxiety may be unable to see family and friends, go on vacation, or travel for work.

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People sometimes ask the doctor or nurse to prescribe diazepam, or similar drugs like lorazepam temazepam or clonazepam, for fear of flying or to help sleep during flights. Prescribing these drugs is not recommended any more for these reasons: The Grange Practice does NOT prescript sedatives for fear of flying.

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Licensed therapist Jules Jean-Pierre of Grow Therapy suggests that the more common fears associated with flying are the fears of dying, small spaces (claustrophobia), motion sickness, getting COVID, and judgment from fellow passengers, among others.

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The FAA encourages pilots to seek help if they have a mental health condition since most, if treated, do not disqualify a pilot from flying.

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Try sitting in an aisle seat in an exit row towards the front of the plane. These seats typically have more legroom, are easier to get out of, and also reduce the number of other passengers in your view, making the space feel less crowded.

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