All the varieties of Tuscan reds can be found throughout Florence, but the most popular are Chianti and Chianti Classico. Other varieties favored in the city are the Brunello di Montalcino, the Carmignano, the Vernaccia of San Gimignano, and the Vino Nobile of Montepulciano.

Florence is the gateway to the Chianti Classico region, making Chianti the most famous wine you will encounter in the city. To be "Classico," the wine must come from the historical heartland between Florence and Siena and is easily identified by the Black Rooster (Gallo Nero) seal on the neck of the bottle. The primary grape is Sangiovese, which produces a medium-bodied red with high acidity and notes of cherry and earth—perfect for pairing with the famous Bistecca alla Fiorentina. Beyond Chianti, Florence is a hub for "Super Tuscans" like Tignanello, which blend Sangiovese with international varieties like Cabernet Sauvignon. For those seeking something even more prestigious, Brunello di Montalcino (100% Sangiovese) is widely available in Florentine enoteche. If you prefer white wine, the nearby Vernaccia di San Gimignano is a historic local favorite. In 2026, there is also a growing trend toward "natural" Tuscan wines, which emphasize minimal intervention and can be found in the smaller, trendy wine bars across the Oltrarno district.