The "best" airport depends on your specific destination within the region, but Tuscany has two primary international gateways. Pisa International Airport (PSA), also known as Galileo Galilei, is the largest and generally the best option for those visiting the coast, Lucca, or looking for budget carrier flights from across Europe. Florence Airport (FLR), or Amerigo Vespucci, is much closer to the regional capital and ideal for those focusing on the Renaissance heart of the city, though its shorter runway sometimes limits the size of aircraft and can lead to more weather-related diversions. For travelers coming from outside Europe, particularly North America, flying into Rome Fiumicino (FCO) is often the most practical and cost-effective choice, as it offers a high-speed train connection that reaches Florence in about 90 minutes.