If you are traveling between Florence and Cinque Terre in 2026, the most iconic and rewarding stop is the city of Pisa. Located about an hour west of Florence, it allows you to see the Leaning Tower and the Cathedral in the Piazza dei Miracoli with just a 2-hour detour. If you prefer a more medieval, "walled city" vibe, Lucca is a fantastic alternative; its perfectly preserved Renaissance walls are topped with a 4-kilometer park where you can rent a bike and ride around the entire city center. For those driving, a stop in Pistoia offers a "mini-Florence" feel with far fewer crowds. If you are taking the train, you will almost certainly have to change in La Spezia, which itself has a lovely waterfront and naval museum worth a quick visit before you board the "Cinque Terre Express" to the five villages. Each stop offers a unique slice of Tuscan or Ligurian culture.