Steve and Elaine Wynn attend a Frank Sinatra concert after party at Le Cirque in New York City in 1985. Born Elaine Farrell Pascal on April 28, 1942, Elaine met Steve when they were in college and married him in 1963.

While the Wynn hotels (Wynn Las Vegas and Encore) are now corporate-owned, the "wife" most associated with the brand's history is Elaine Wynn, often called the "Queen of Las Vegas." She was married to the hotel's founder, Steve Wynn, twice (1963–1986 and 1991–2010) and played a pivotal role in the design and corporate strategy of the resort empire for decades. However, the current wife of Steve Wynn is Andrea Hissom, whom he married in a lavish ceremony at the Wynn Las Vegas in April 2011. Andrea is a socialite and the great-niece of Ben Novack, the developer of the Fontainebleau Miami Beach. Following Steve Wynn's resignation from Wynn Resorts in 2018 amid controversy, the couple has largely stayed out of the public corporate spotlight. Andrea is known for her philanthropic work and her influence on the high-end aesthetic of the Wynns' personal estates, though Elaine Wynn remains the largest individual shareholder and a significant power player in the Las Vegas business community.